HCID 71272259, compound → HCID 71272197, compound

Participants

Reaction Steps

A mixture of 5-fluoro-1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazole-6-carbonitrile (1.2 g, 4.9 mmol) and Raney nickel (40 mg) in NH3/MeOH solution (7 N, 20 mL) was stirred under hydrogen at RT overnight. The reaction mixture was filtered through Celite® and the filtrate concentrated in vacuo to afford (5-fluoro-1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-6-yl)methanamine as an oil (350 mg, 28.7%). MS (ESI): m/z=250 [M+1]+.

Provenance & Evidence