N-methyl-2-pyrrolidone → HCID 71272741, compound

Participants

Reaction Conditions

Reaction Steps

A sealed-cap vial was charged with 4-bromo-1-(tetrahydro-2H-pyran-2-yl)-6-(trifluoromethyl)-1H-indazole (1.03 g, 2.95 mmol), Zn(CN)2 (0.38 g, 3.24 mmol), Pd(PPh3)4 (0.24 g, 0.21 mmol), and NMP (8 mL). The mixture was degassed for 5 min under nitrogen and the mixture then stirred under nitrogen at 85° C. for 16 h. The mixture was filtered and the filtrate concentrated in vacuo. The crude mixture was purified by SiO2 chromatography to afford 1-(tetrahydro-2H-pyran-2-yl)-6-(trifluoromethyl)-1H-indazole-4-carbonitrile as a solid (0.69 g, 79%). MS (ESI) m/z: 296.3 [M+1]+.

Provenance & Evidence