HCID 71272741, compound → HCID 71272561, compound

Participants

Reaction Steps

To a solution of 1-(tetrahydro-2H-pyran-2-yl)-6-(trifluoromethyl)-1H-indazole-4-carbonitrile (440 mg, 1.49 mmol) in ammonia (2M solution in methanol, 10 mL) was added Raney-Ni (1.27 g, suspension in water). The mixture was stirred under a hydrogen atmosphere (1 atm.) at RT for 16 h and then filtered. The filtrate was concentrated in vacuo to afford crude (1-(tetrahydro-2H-pyran-2-yl)-6-(trifluoromethyl)-1H-indazol-4-yl)methanamine (127, 267 mg, yield: 60%). MS (ESI) m/z: 300.2 [M+1]+.

Provenance & Evidence