6-methoxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carbonitrile → (6-Methoxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)methanamine

Participants

Reaction Steps

To a solution of 6-methoxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-4-carbonitrile (350 mg, 1.36 mmol) in ammonia (2M solution in methanol, 15 mL) was added Raney-Ni (1.17 g, suspension in water). The mixture was stirred under a hydrogen atmosphere (1 atm.) at RT for 16 h and then filtered. The filtrate was concentrated in vacuo to afford crude (6-methoxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)methanamine (129, 270 mg, yield: 76%). MS (ESI) m/z: 262.4 [M+1]+.

Provenance & Evidence