反应详情

温度

0 °C

Thionyl chloride (10 mL) was added dropwise to a solution of 1H-benzo[d]imidazole-5-carboxylic acid (4.8 g, 30 mmol) in MeOH (150 mL) cooled to 0° C. The reaction mixture was heated at reflux for 18 h, and then solvent (about 2/3) was concentrated under reduced pressure. After cooling, a yellow solid was precipitated from the solution and was filtered to afford 4 g (90%) of methyl 1H-benzo[d]imidazole-5-carboxylate (20): MS (ESI) m/z=177 [M+1]+.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 18 h
3. concentrationsolvent (about 2/3) was concentrated under reduced pressure
4. temperatureAfter cooling
5. customa yellow solid was precipitated from the solution
6. filtrationwas filtered