4-Toluenesulfonyl chloride → 1-tosyl-1H-indole-6-carbonitrile

Participants

Reaction Steps

To a solution of 1H-indole-6-carbonitrile (70 mg, 0.5 mmol, CASRN 15861-36-6) in THF (5 mL) cooled to 0° C. was added with vigorous stirring NaH (25 mg, 60% in oil, 0.65 mmol). After stirring for 30 min, TsCl (140 mg, 0.75 mmol) was added to the mixture. The reaction mixture was stirred at RT for 18 h then partitioned between DCM (300 mL) and water (50 mL). The organic layer was separated, dried (MgSO4), filtered and concentrated in vacuo. The resulting residue was purified by SiO2 chromatography eluting with a petroleum ether/EtOAc gradient (5 to 10% EtOAc) to afford 100 mg (67%) of 1-tosyl-1H-indole-6-carbonitrile (34) as a white solid: MS (ESI) m/z=297.1 [M+1]+.

Provenance & Evidence