反应详情

To a solution of 34 (100 mg, 0.34 mmol) and 7 M ammonia solution in MeOH (5 mL) was added Raney Ni (10 mg) and the mixture was stirred vigorously under H2 (1 atm.) atmosphere at RT for 18 h. The catalyst was filtered was and the filtrate concentrated in vacuo to afford 80 mg (78%) of (1-tosyl-1H-indol-6-yl)methanamine (36) as syrup: MS (ESI) m/z=301.2 [M+1]+.

1. filtrationThe catalyst was filtered
2. concentrationthe filtrate concentrated in vacuo