HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475183Generated: October 26, 2026
Pyridine → 1-tosyl-1H-indole-4-carbaldehyde oxime
https://huagongshe.com/reaction/475183
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | 1-Tosyl-1H-indole-4-carbaldehyde | HCID 13115093 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-tosyl-1H-indole-4-carbaldehyde oxime | HCID 86694720 | 85% |
Reaction Steps
To a solution of 42 (900 mg, 3 mmol) in EtOH (10 mL) was added hydroxylamine hydrochloride (1.0 g, 15 mmol) and pyridine (1.0 mL). After the reaction mixture was stirred at 70° C. overnight, the solvent was removed in vacuo to afford 800 mg (85%) of 1-tosyl-1H-indole-4-carbaldehyde oxime (44) as white solid: MS (ESI) m/z=315 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08637537B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-40ea97fd2cd847f084ce7715e43f56d0 |
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| Source note | uspto-grants-2014_01 |
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