HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475191Generated: October 25, 2026
p-Toluenesulfonic acid monohydrate → N2-((1H-benzo[d]imidazol-4-yl)methyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
https://huagongshe.com/reaction/475191
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Reactant | N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-((1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-4-yl)methyl)pyrimidine-2,4-diamine | HCID 86694722 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | N2-((1H-benzo[d]imidazol-4-yl)methyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | HCID 71529299 | — |
Reaction Steps
A mixture of 60 (110 mg, 0.26 mmol) and p-TsOH.H2O (44 mg, 0.26 mmol) in MeOH (5 mL) and water (1 mL) was heated at 80° C. for 14 h. The solvent was removed in vacuo. The crude product was purified by preparative HPLC to afford 45 mg (51%) I-39 as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637537B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-7452a1575c3a4dd9b05983798aa43d8e |
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| Source note | uspto-grants-2014_01 |
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