反应详情

To a solution of 104 (245 mg, 1.0 mmol) in 7N NH3 in MeOH (20 mL) was added Ra—Ni (50 mg), and then it was stirred under hydrogen (1 atm) at RT overnight. The dark mixture was filtered and the filtrate was concentrated in vacuo to afford 230 mg (96%) of (6-fluoro-1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-5-yl)methanamine (106) as yellow oil: MS (ESI): m/z=250 [M+1]+.

1. filtrationThe dark mixture was filtered
2. concentrationthe filtrate was concentrated in vacuo