反应详情

温度

75 °C

To a solution of 1,3-difluoro-2-nitro-benzene (30 g, 0.188 moles) in EtOH (300 mL) was added 25% aq. ammonia solution (300 mL) and the resulting mixture was heated to 75° C. for 16 h then cooled and concentrated in vacuo. The residue was dissolved in EtOAc, washed with water and brine solution, dried (Na2SO4), filtered and concentrated to afford 25 g (85%) of 3-fluoro-2-nitro-phenylamine (138) as a brown solid which was used without any further purification.

1. temperaturethen cooled
2. concentrationconcentrated in vacuo
3. dissolutionThe residue was dissolved in EtOAc
4. washwashed with water and brine solution
5. dry with materialdried (Na2SO4)
6. filtrationfiltered
7. concentrationconcentrated