反应详情

A mixture of 142 (25 g, 0.121 mol) and formic acid (75 mL) was heated to reflux for 1.5 h. After the completion of the reaction the reaction was cooled and made basic with 10% NaOH. The resulting solid was filtered and washed with water. Drying overnight under suction afforded 24 g (92%) of 5-bromo-4-fluoro-1H-benzoimidazole (144) as pale yellow solid which was used without further purification.

1. temperaturewas heated
2. temperatureto reflux for 1.5 h
3. customAfter the completion of the reaction the reaction
4. temperaturewas cooled
5. filtrationThe resulting solid was filtered
6. washwashed with water
7. customDrying overnight under suction