HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 1-(1-methoxycarbonylpiperidin-4-yl)-piperidin-4-yl-5-methyl-3-(methylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 1-[1-(1-methoxycarbonylpiperidin-4-yl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one | HCID 22745218 | — |
| Reactant | 1-[1-(1-methoxycarbonylpiperidin-4-yl)-piperidin-4-yl]-5-methyl-1,3-dihydro-2H-benzimidazol-2-one | HCID 22745327 | — |
| Product | 1-(1-methoxycarbonylpiperidin-4-yl)-piperidin-4-yl-5-methyl-3-(methylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-one | HCID 9911611 | — |
Reaction Steps
Example 12 was repeated except that the 1-[1-(1-methoxycarbonylpiperidin-4-yl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one was replaced with 1-[1-(1-methoxycarbonylpiperidin-4-yl)-piperidin-4-yl]-5-methyl-1,3-dihydro-2H-benzimidazol-2-one which was synthesized by the method of Referential Example 5 and that acetyl chloride was replaced with methanesulfonyl chloride. The title compound was obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699880B1 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-fa0f41a9aaad46b1ade40d04b28d56b0 |
| Source note | uspto-grants-2004_03 |