HCID 71272633, compound → HCID 86694735, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 176 (4.6 g, 19 mmol) Raney-Ni (>15 eq) in 7N NH3 solution in MeOH (10 mL) was stirred under hydrogen at 25° C. for 2 h. The mixture was filtered and concentrated in vacuo. The crude product was purified by SiO2 chromatography eluting with a MeOH/DCM gradient (3 to 5% MeOH) to afford 3.2 g (69%) of (6-methyl-1-tetrahydropyran-2-yl-benzimidazol-5-yl)methanamine (178) as a yellow oil: MS (ESI) m/z=246 [M+1]+.

Provenance & Evidence