Ammonium Chloride → HCID 71272254, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of 168 (70 mg, 0.24 mmol) and THF cooled to 0° C. under Ar was added EtMgBr (0.72 mL, 1M solution). The mixture was stirred at 0° C. for 2 h then NH4Cl solution was added carefully. The mixture was extracted with EtOAc, washed sequentially with H2O and brine and dried (Na2SO4), filtered and concentrated in vacuo. The crude product was purified by SiO2 chromatography to afford 45 mg (72%) of 1-[1-(tetrahydro-pyran-2-yl)-1H-benzoimidazol-5-yl]-propan-1-one (170) as a colorless oil.

Provenance & Evidence