Hydroxyamine hydrochloride → HCID 86694688, compound

Participants

Reaction Steps

To a solution of 170 (100 mg, 0.39 mmol) in MeOH (5 mL) was added hydroxylamine hydrochloride (54 mg, 0.78 mmol) and NaOAc (100 mg, 1 mmol). The mixture was refluxed overnight. The mixture was extracted with EtOAc, washed sequentially with H2O and brine and dried (Na2SO4), filtered and concentrated in vacuo to afford 95 mg (90%) of 1-[1-(tetrahydro-pyran-2-yl)-1H-benzoimidazol-5-yl]-propan-1-one oxime (172) as a light yellow oil.

Provenance & Evidence