HCID 86694688, compound → HCID 86694736, compound

Participants

Reaction Steps

To a solution of 172 (30 mg, 0.11 mmol) in THF (3 mL) was added Raney-Ni (50 mg) and the mixture was stirred at RT overnight, filtered and concentrated in vacuo. Purification by HPLC afforded 10 mg (35%) of 1-(1-tetrahydropyran-2-ylbenzimidazol-5-yl)propan-1-amine (174) as a colourless oil: 1H NMR (400 MHz, CDCl3): δ 7.98 (m, 1H), 7.64 (m, 1H), 7.40 (m, 1H), 7.14-7.36 (m, 1H), 5.40-5.45 (m, 1H), 4.06 (m, 1H), 3.85 (m, 1H), 3.70 (m, 1H), 2.02-2.10 (m, 3H), 1.62-1.72 (m, 8H), 0.77-0.84 (m, 3H); MS (ESI+) m/z=260 [M+1]+.

Provenance & Evidence