反应详情

To a solution of 232 (200 mg, 1.28 mmol) in 7 N NH3 in MeOH (10 mL) was added Raney nickel (20 mg) and the solution was stirred under hydrogen (1 atm.) at RT overnight. The dark mixture was filtered and the filtrate was concentrated under reduced pressure to afford 200 mg (91%) (3-methyl-1H-indol-4-yl)methanamine (234) as white solid: MS (ESI) m/z=144.3 [M−16]+.

1. filtrationThe dark mixture was filtered
2. concentrationthe filtrate was concentrated under reduced pressure