HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 1-[1-(1-ethoxycarbonylpiperidin-4-yl)-piperidin-4-yl]-3-methyl-1,3-dihydro-2H-benzimidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | 1-[1-(1-methoxycarbonylpiperidin-4-yl)piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one | HCID 22745218 | — |
| Reactant | HCID 22745278 | HCID 22745278 | — |
| Product | 1-[1-(1-ethoxycarbonylpiperidin-4-yl)-piperidin-4-yl]-3-methyl-1,3-dihydro-2H-benzimidazol-2-one | HCID 9864996 | — |
Reaction Steps
Example 1 was repeated except that the propargyl bromide was replaced with methyl iodide and 1-[1-(1-methoxycarbonylpiperidin-4-yl)-piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one was replaced with 1-[1-(1-ethoxycarbonylpiperidin-4-yl-piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one which was synthesized by the method of Referential Example 16, and the title compound was obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06699880B1 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-3a6f96770b774be6b65c81ddcc0f583e |
| Source note | uspto-grants-2004_03 |