HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475285Generated: October 30, 2026
Diisopropylethylamine → HCID 178505998, compound
https://huagongshe.com/reaction/475285
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-chloro-N-(3-cyclopropyl-1H-pyrazol-5-yl)-5-fluoropyrimidin-4-amine | HCID 58169306 | — |
| Reactant | (1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-4-yl)methanamine | HCID 71272654 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 178505998 | HCID 178505998 | 57% |
Reaction Steps
A tube was charged with 58 (273 mg, 1.18 mmol), 55 (150 mg, 0.59 mmol), DIPEA (0.5 ml) and IPA (4 mL), degassed, sealed and heated at 120° C. for 72 h. The solvent was evaporated in vacuo to afford 150 mg (57%) of N4-(3-cyclopropyl-1H-pyrazol-5-yl)-5-fluoro-N2-((1-(tetrahydro-2H-pyran-2-yl)-1H-benzo[d]imidazol-4-yl)methyl)pyrimidine-2,4-diamine (280)—as yellow solid: MS (ESI) m/z=449.7 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637537B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-529d1c31229b4f4f8d2942bdac9b4739 |
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| Source note | uspto-grants-2014_01 |
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