HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-methyl-1H-indole-4-carbonitrile → (5-methyl-1H-indol-4-yl)methanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-methyl-1H-indole-4-carbonitrile | HCID 76846734 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (5-methyl-1H-indol-4-yl)methanamine | HCID 76846757 | 95.7% |
Reaction Steps
A mixture of 302 (54 mg, 0.346 mmol) and Raney Ni (100 mg) in 7M ammonia in MeOH (20 mL) was stirred under hydrogen at RT for 3 h. It was filtered through Celite®, and the filtrate was concentrated under reduced pressure to afford 53 mg (95.7%) of (5-methyl-1H-indol-4-yl)methanamine (304) as yellow solid: MS (ESI) m/z=144.3 (M−16).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637537B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-7385944bd4a941fa9eef6221007e81fa |
| Source note | uspto-grants-2014_01 |