HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475299Generated: October 29, 2026
Diisopropylethylamine → N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((5-methyl-1H-indol-4-yl)methyl)pyrimidine-2,4-diamine
https://huagongshe.com/reaction/475299
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (5-methyl-1H-indol-4-yl)methanamine | HCID 76846757 | — |
| Reactant | HCID 178478345 | HCID 178478345 | — |
| Product | N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((5-methyl-1H-indol-4-yl)methyl)pyrimidine-2,4-diamine | HCID 86694757 | — |
Reaction Steps
A mixture of 304 (53 mg, 0.331 mmol) 53 (94 mg, 0.397 mmol), and DIPEA (128 mg, 0.993 mmol) in WA (2 mL) under nitrogen atmosphere was heated in a sealed tube at 120° C. for 18 h. The crude was purified by preparative HPLC to afford 38 mg (32%) of I-122.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637537B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-b4b8e60fe6c346e6bd1b0cf705e7f0a7 |
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| Source note | uspto-grants-2014_01 |
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