HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1h-Indol-5-yl)ethylamine adipate → N2-((4-chloro-1H-indol-5-yl)methyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-6-methylpyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1h-Indol-5-yl)ethylamine adipate | HCID 52993441 | — |
| Reactant | 2-chloro-N-(3-cyclopropyl-1H-pyrazol-5-yl)-6-methylpyrimidin-4-amine | HCID 59819615 | — |
| Reactant | tert-butyl 5-(aminomethyl)-4-chloro-1H-indole-1-carboxylate | HCID 71272344 | — |
| Reactant | HCID 178478345 | HCID 178478345 | — |
| Product | N2-((4-chloro-1H-indol-5-yl)methyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-6-methylpyrimidine-2,4-diamine | HCID 86694737 | — |
Reaction Steps
N2-((4-chloro-1H-indol-5-yl)methyl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-6-methylpyrimidine-2,4-diamine (I-19) was prepared using procedure analogous to the preparation of I-8, step 1, except 2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-6-methyl-pyrimidin-4-amine 185 and tert-butyl 5-(aminomethyl)-4-chloro-1H-indole-1-carboxylate were used in place of 53 and 1-(1H-indol-5-yl)ethanamine adipic acid salt, respectively, to afford I-19; MS (ESI) m/z=394.1 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637537B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-643f4f5e95d94045b3eaad172b52906f |
| Source note | uspto-grants-2014_01 |