HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475317Generated: October 30, 2026
Urea → 6-Bromo-8-methoxyquinazolin-2(1H)-one
https://huagongshe.com/reaction/475317
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | 2-Amino-5-bromo-3-methoxybenzaldehyde | HCID 15380445 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-Bromo-8-methoxyquinazolin-2(1H)-one | HCID 53438807 | — |
Reaction Steps
2-amino-5-bromo-3-methoxybenzaldehyde (2.5 g, 10.87 mmol) is homogeneously mixed with urea and the mixture is heated to 180° C. The melt formed is kept at this temperature for 1 h. Then the reaction mixture is mixed with water, the precipitate formed is filtered off, dried and 6-bromo-8-methoxy-1H-quinazolin-2-one (HPLC-MS: tRet.=1.53 min MS(M+H)+=255/257; method FSUN) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08637549B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-d54da5bf201a470b93c70f92d8160d29 |
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| Source note | uspto-grants-2014_01 |
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