HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-Bromo-2-chloro-8-methoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-Bromo-8-methoxyquinazolin-2(1H)-one | HCID 53438807 | — |
| Product | 6-Bromo-2-chloro-8-methoxyquinazoline | HCID 46738296 | — |
Reaction Steps
6-bromo-8-methoxy-1H-quinazolin-2-one (2.62 g, 10.27 mmol) is suspended in 30 mL POCl3 and refluxed for 30 min. The reaction mixture is stirred into water, while the temperature never exceeds 15° C. The aqueous phase is extracted with DCM, the organic phase is dried and 6-bromo-2-chloro-8-methoxy-quinazoline (HPLC-MS: tRet.=1.88 min, MS(M+H)+=273/275/277; method FSUN) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637549B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-3a2ade1bf8664602b86a7741802fd93e |
| Source note | uspto-grants-2014_01 |