Boron tribromide → HCID 57461135, compound

HRID 475319Notes

Reaction equation

HRID 475319 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([O:12]C)[CH:11]=1)[N:8]=[C:7]([Cl:14])[N:6]=[CH:5]2.B(Br)(Br)Br>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([OH:12])[CH:11]=1)[N:8]=[C:7]([Cl:14])[N:6]=[CH:5]2

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 467382966-Bromo-2-chloro-8-methoxyquinazoline

Product 1

HCID 57461135HCID 57461135, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
20 °C

Procedure

6-bromo-2-chloro-8-methoxy-quinazoline (1.24 g, 4.52 mmol) is taken up in 7 mL DCM, combined with boron tribromide (12.95 mL, 12.95 mmol) and stirred for 2 d at 20° C. Then the mixture is diluted with ice water, the precipitate formed is filtered off, dried and 6-bromo-2-chloro-quinazolin-8-ol (HPLC-MS: tRet.=1.77 min; method FSUN) is obtained.

Workup

  1. customthe precipitate formed
  2. filtrationis filtered off
  3. customdried

Sources & evidence

ORD record
ord-c4a49b37688f405abdd63d98d5831ec6
Source dataset
uspto-grants-2014_01
Patent number
US08637549B2

Reaction notes

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