HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → 1-(2-Chloro-4-isopropylaminopyrimidin-5-yl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Cyclohexane | HCID 8078 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1-(2,4-Dichloropyrimidin-5-yl)ethan-1-one | HCID 21274708 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(2-Chloro-4-isopropylaminopyrimidin-5-yl)-ethanone | HCID 57461137 | — |
Reaction Steps
1-(2,4-dichloro-pyrimidin-5-yl)-ethanone (10 g, 0.052 mol), sodium hydrogen carbonate (19.35 g, 0.058 mol) and isopropylamine (5 mL, 0.058 mol) are taken up in 35 mL THF and 200 mL cyclohexane and stirred for 2 h at 20° C. The reaction solution is filtered through silica gel, the solvent is eliminated in vacuo and 1-(2-chloro-4-isopropylaminopyrimidin-5-yl)-ethanone (HPLC-MS: tRet.=1.73 min, MS(M+H)+=214/216; method FECB3) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637549B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-68033b788dce4a37b212e189f222e7ac |
| Source note | uspto-grants-2014_01 |