HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475323Generated: October 30, 2026
Sodium methanethiolate → 1-(4-Isopropylamino-2-methylsulphanyl-pyrimidin-5-yl)-ethanone
https://huagongshe.com/reaction/475323
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | 1-(2-Chloro-4-isopropylaminopyrimidin-5-yl)-ethanone | HCID 57461137 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(4-Isopropylamino-2-methylsulphanyl-pyrimidin-5-yl)-ethanone | HCID 57461138 | — |
Reaction Steps
1-(2-chloro-4-isopropylamino-pyrimidin-5-yl)-ethanone (11.1 g, 0.052 mol) and sodium thiomethoxide (5.75 g, 0.078 mol) are taken up in 100 mL dioxane and stirred for 16 h at 20° C. The solvent is eliminated in vacuo, the residue is taken up in ethyl acetate and extracted 2× with water. The organic phase is dried, the solvent is eliminated in vacuo and 1-(4-isopropylamino-2-methylsulphanyl-pyrimidin-5-yl)-ethanone (HPLC-MS: tRet.=1.82 min, MS(M+H)+=226; method FECB3) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637549B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-4a5c0785809c4dd29db6dfe98656c3a2 |
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| Source note | uspto-grants-2014_01 |
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