Hydrochloric Acid → HCID 66848355, compound

Participants

Reaction Steps

To a solution of (S)—N-((1S)-1-(2-(6-bromobenzo[d]isoxazol-3-yl)phenyl)-2-(pyridin-2-yl)ethyl)-2-methylpropane-2-sulfinamide (Compound 14a) (1.76 g) dissolved in dichloromethane (10 mL) was added 2N hydrochloric acid (10 mL) and the mixture left to stand at room temperature. The resulting mixture was taken up in methanol and loaded onto a 20 g SCX column and eluted with neat methanol, followed by ammonia-methanol and the fractions containing product were evaporated to give the title product (1.25 g) as a clear yellow oil.

Provenance & Evidence