HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86675997, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 70802833 | HCID 70802833 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86675997 | HCID 86675997 | — |
Reaction Steps
To a solution of 3-(2-(1(S)-(tert-butoxycarbonylamino)-2-(pyridin-2-yl)ethyl) -phenyl)benzo[d]isoxazole-6-carboxylic acid (Compound 18a) (45 mg) dissolved in dry dichloromethane (2 mL) under nitrogen, cooled with ice bath, was added triethylamine (127 μL) then thionyl chloride (35.5 μL). After 10 min the solvents were removed under reduced pressure to give the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637551B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-1c3e36b0ae5f4064b02ce7b703040aaa |
| Source note | uspto-grants-2014_01 |