HCID 58505479, compound → HCID 44236893, compound

Participants

Reaction Steps

5-(4-Nitro-phenyl)-furan-2-carboxylic acid ((S)-cyclohexyl-methylcarbamoyl-methyl)-amide (760 mg, 1.96 mmol), acetic acid 15 mL and zinc (1.2 g, 19 mmol) are combined and stirred at room temperature for 30 minutes. The crude reaction mixture is filtered through celite, washed with acetonitrile and the combined washings concentrated in vacuo. The crude material is taken up in 10% methanol in DCM and washed with saturated aqueous sodium bicarbonate. The organic layer is dried, filtered and evaporated in vacuo to yield the title compound that is used without further purification, 660 mg, 94%, LC/MS ESI m/z (M+H)+=356.2.

Provenance & Evidence