Methanol → HCID 58399162, compound

Participants

Reaction Conditions

Reaction Steps

To a 0° C. solution of (+/−) 4-fluoro-N-methyl-N-(6,7,8,9-tetrahydropyrido [1,2-α]indol-7-yl)benzenesulfonamide from Step 11 in CH2Cl2 (0.1 M) was added oxalyl chloride (2 equiv.) and the mixture was stirred for 1 h at 0° C. MeOH (20 equiv.) was added, the resulting mixture was stirred at rt for 1 h, and then poured into aqueous NaHCO3 and extracted with CH2Cl2 (2×). The combined organic layers were washed with brine, dried with MgSO4 and concentrated under vacuum to afford the crude title compound (100%) as a yellow solid. The material was used as such in the next step.

Provenance & Evidence