反应详情

Rhodium (II) octanoate dimer (0.1 equiv.) was added to a CH2Cl2 solution (0.02 M) of propyl [2-(4-diazo-3-oxobutyl)-1H-indo1-3-yl]acetate from Step 4. The reaction mixture was stirred overnight at rt and then concentrated. The residue was purified by column chromatography on silica gel using a CombiFlashRF (Teledyne ISCO) eluting with EtOAc/Hex (2:98 to 10:90) to give the title compound (64%) as a yellow solid.

1. concentrationconcentrated
2. customThe residue was purified by column chromatography on silica gel using a CombiFlashRF (Teledyne ISCO)
3. washeluting with EtOAc/Hex (2:98 to 10:90)