Hydrochloric Acid → HCID 23135143, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the intermediate from step A (25 mg, 0.089 mmol) in 2-propanol (1 mL) was added water (2 mL), sodium azide (14 mg, 0.222 mmol) and zinc bromide (10 mg, 0.04 mmol). After heating the reaction mixture at 90° C. for 18 hours, it was cooled to room temperature and HCl (3 mL, 3N) was added. The reaction mixture was extracted with ethyl acetate, washed with brine, dried over anhydrous Na2SO4 filtered and concentrated in vacuo. The residue was purified by PTLC (SiO2) using 100% ethyl acetate to give the desired product.

Provenance & Evidence