HCID 68982390, compound → HCID 68981450, compound

HRID 475561Notes

Reaction equation

HRID 475561 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C:17]2[O:18][CH:19]=[C:20]([CH2:22][NH:23][C:24](=[O:34])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[O:31][CH2:32][CH3:33])[N:21]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])C1C=CC=CC=1.[H][H]>C(O)C.[C].[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([C:17]2[O:18][CH:19]=[C:20]([CH2:22][NH:23][C:24](=[O:34])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[O:31][CH2:32][CH3:33])[N:21]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

Participants

5

Reactant 2

HCID 68982390HCID 68982390, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68981450HCID 68981450, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A 4.65 g quantity of the N-[2-(3-benzyloxy-4-methoxyphenyl)oxazol-4-ylmethyl]-2-ethoxybenzamide obtained in Example 1 was dissolved in 90 ml of ethanol, and 0.45 g of 10% palladium carbon powder was added thereto. The mixture was stirred in a hydrogen atmosphere at room temperature for one hour. The catalyst was removed by filtration, and the filtrate was then concentrated under reduced pressure to give 3.7 g of white crystalline N-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-ylmethyl]-2-ethoxybenzamide.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was then concentrated under reduced pressure

Sources & evidence

ORD record
ord-0a3355baa01f44d4ab4536d2e8b59346
Source dataset
uspto-grants-2014_01
Patent number
US08637559B2

Reaction notes

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