HCID 68983388, compound → HCID 68981662, compound

HRID 475565Notes

Reaction equation

HRID 475565 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C:17]2[O:18][CH:19]=[C:20]([CH2:22][NH:23][C:24](=[O:32])[C:25]3[C:30]([CH3:31])=[CH:29][CH:28]=[CH:27][N:26]=3)[N:21]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])C1C=CC=CC=1.[H][H]>C(O)C.[C].[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([C:17]2[O:18][CH:19]=[C:20]([CH2:22][NH:23][C:24](=[O:32])[C:25]3[C:30]([CH3:31])=[CH:29][CH:28]=[CH:27][N:26]=3)[N:21]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

Participants

5

Reactant 2

HCID 68983388HCID 68983388, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 68981662HCID 68981662, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

A 1.5 g quantity of the N-[2-(3-benzyloxy-4-methoxy phenyl)oxazol-4-ylmethyl]-3-methylpicolinamide obtained in Example 16 was dissolved in 50 ml of ethanol, and 0.1 g of 10% palladium carbon powder was added thereto. The mixture was stirred in a hydrogen atmosphere at 50° C. for two hours. The catalyst was removed by filtration, and the filtrate was then concentrated to give 1.3 g of white crystalline N-[2-(3-hydroxy-4-methoxyphenyl)oxazol-4-ylmethyl]-3-methylpicolinamide.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was then concentrated

Sources & evidence

ORD record
ord-41e5291917f545e995a406d4815046a0
Source dataset
uspto-grants-2014_01
Patent number
US08637559B2

Reaction notes

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