HCID 68981657, compound → HCID 68984051, compound

HRID 475571Notes

Reaction equation

HRID 475571 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C:19]2[O:20][CH:21]=[C:22]([CH2:24][NH:25][C:26](=[O:34])[C:27]3[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][N:28]=3)[N:23]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH:16]([F:18])[F:17])C1C=CC=CC=1>C(O)C.[C].[Pd]>[F:18][CH:16]([F:17])[O:15][C:14]1[CH:13]=[CH:12][C:11]([C:19]2[O:20][CH:21]=[C:22]([CH2:24][NH:25][C:26](=[O:34])[C:27]3[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][N:28]=3)[N:23]=2)=[CH:10][C:9]=1[OH:8]

Participants

4

Reactant 1

HCID 68981657HCID 68981657, compound

Product 1

HCID 68984051HCID 68984051, compoundYield 93%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

0.16 g of N-[2-(3-benzyloxy-4-difluoromethoxyphenyl)oxazol-4-ylmethyl]-3-methylpicolinamide obtained in Example 96 was dissolved in 5 ml of ethanol, 20 mg of 10% palladium carbon powder was added thereto, and the mixture was stirred at room temperature for 30 minutes under a hydrogen atmosphere. The catalyst was filtered off, and the filtrate was concentrated to obtain 0.12 g of white powdery N-[2-(4-difluoromethoxy-3-hydroxyphenyl)oxazol-4-ylmethyl]-3-methylpicolinamide.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-404ecd46d6ff401681210736bb119e6e
Source dataset
uspto-grants-2014_01
Patent number
US08637559B2

Reaction notes

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