1-Bromo-2-methylpropane → HCID 57855784, compound

HRID 475608Notes

Reaction equation

HRID 475608 reaction equation
[F:1][CH:2]([F:29])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:28])[CH2:12][CH2:13][C:14]1[N:15]=[C:16]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([OH:27])[CH:20]=2)[O:17][CH:18]=1.[CH2:30](Br)[CH:31]([CH3:33])[CH3:32]>>[F:29][CH:2]([F:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:28])[CH2:12][CH2:13][C:14]1[N:15]=[C:16]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([O:27][CH2:30][CH:31]([CH3:33])[CH3:32])[CH:20]=2)[O:17][CH:18]=1

Participants

3

Reactant 2

HCID 65551-Bromo-2-methylpropaneHCID 86633758HCID 86633758, compound

Product 1

HCID 57855784HCID 57855784, compound

Procedure

Using the compound obtained in Example 272 and isobutyl bromide, white powdery 1-[2-(2,2-difluoroethoxy)phenyl]-3-[2-(3-isobutoxy-4-methoxyphenyl)oxazol-4-yl]-propan-1-one was obtained following the procedure of Example 3.

Sources & evidence

ORD record
ord-d940a740d05d444d90124883eaad2cf3
Source dataset
uspto-grants-2014_01
Patent number
US08637559B2

Reaction notes

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