1-Bromo-2-methylpropane → HCID 25142023, compound

HRID 475635Notes

Reaction equation

HRID 475635 reaction equation
[F:1][CH:2]([F:27])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][CH:12]=[C:13]([CH2:15][NH:16][C:17](=[O:25])[C:18]3[C:23]([CH3:24])=[CH:22][CH:21]=[CH:20][N:19]=3)[N:14]=2)=[CH:6][C:5]=1[OH:26].[CH2:28](Br)[CH:29]([CH3:31])[CH3:30]>>[F:27][CH:2]([F:1])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][CH:12]=[C:13]([CH2:15][NH:16][C:17](=[O:25])[C:18]3[C:23]([CH3:24])=[CH:22][CH:21]=[CH:20][N:19]=3)[N:14]=2)=[CH:6][C:5]=1[O:26][CH2:28][CH:29]([CH3:31])[CH3:30]

Participants

3

Reactant 2

HCID 65551-Bromo-2-methylpropaneHCID 68984051HCID 68984051, compound

Product 1

HCID 25142023HCID 25142023, compound

Procedure

Using the compound obtained in Example 97 and isobutyl bromide, colorless oily N-[2-(4-difluoromethoxy-3-isobutoxy phenyl)oxazol-4-ylmethyl]-3-methylpicolinamide was obtained following the procedure of Example 3.

Sources & evidence

ORD record
ord-fcc5cce718fd47818d9fa0538e66384f
Source dataset
uspto-grants-2014_01
Patent number
US08637559B2

Reaction notes

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