(Bromomethyl)cyclobutane → HCID 68981865, compound

HRID 475659Notes

Reaction equation

HRID 475659 reaction equation
[F:1][CH:2]([F:29])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][CH:12]=[C:13]([CH2:15][NH:16][C:17](=[O:27])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][CH2:25][CH3:26])[N:14]=2)=[CH:6][C:5]=1[OH:28].Br[CH2:31][CH:32]1[CH2:35][CH2:34][CH2:33]1>>[CH:32]1([CH2:31][O:28][C:5]2[CH:6]=[C:7]([C:10]3[O:11][CH:12]=[C:13]([CH2:15][NH:16][C:17](=[O:27])[C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[O:24][CH2:25][CH3:26])[N:14]=3)[CH:8]=[CH:9][C:4]=2[O:3][CH:2]([F:1])[F:29])[CH2:35][CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 2734658(Bromomethyl)cyclobutaneHCID 68983382HCID 68983382, compound

Product 1

HCID 68981865HCID 68981865, compound

Procedure

Using the compound obtained in Example 347 and (bromomethyl)cyclobutane, white powdery N-[2-(3-Cyclobutylmethoxy-4-difluoromethoxyphenyl)oxazol-4-ylmethyl]-2-ethoxybenzamide was obtained following the procedure of Example 348.

Sources & evidence

ORD record
ord-d18d8b1a8c3d45c5b544c37a481f6b42
Source dataset
uspto-grants-2014_01
Patent number
US08637559B2

Reaction notes

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