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HRID475757

反应详情

EQUATION

反应方程式

HRID 475757 的结构方程式

REACTANTS

反应物

2
结构：OC1(C(F)(F)F)CCNC1
HCID50990624

未命名化合物

结构：Fc1ccc(C2CCc3c(Cl)nc(Cl)nc32)cc1
HCID58075424

未命名化合物

PRODUCTS

生成物

1
结构：OC1(C(F)(F)F)CCN(c2nc(Cl)nc3c2CCC3c2ccc(F)cc2)C1
HCID58075636

未命名化合物

收率 62%

PROCEDURE

实验过程

2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine (Preparation H) (286 mg, 1.010 mmol) and 3-(trifluoromethyl)pyrrolidin-3-ol (157 mg, 1.010 mmol) were combined and purified as per Preparation Hb to give 1-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-(trifluoromethyl)pyrrolidin-3-ol (62% yield). LC-MS (M+H)+=402.0.

WORKUP

后处理

  1. custompurified as per Preparation Hb