HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Dimethylamino)pyrrolidine → HCID 58075613, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Dimethylamino)pyrrolidine | HCID 2758519 | — |
| Reactant | 2,4-Dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[D]pyrimidine | HCID 58075424 | — |
| Product | HCID 58075613 | HCID 58075613 | 86% |
Reaction Steps
2,4-dichloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine (Preparation H) (100 mg, 0.353 mmol) and N,N-dimethylpyrrolidin-3-amine (44.3 μL, 0.353 mmol) were combined and purified as per Preparation Hb to give 1-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-N,N-dimethylpyrrolidin-3-amine (109 mg, 86% yield). LC-MS (M+H)+=361.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08637525B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-6ad128634880421398ce5d38b06cd4f2 |
| Source note | uspto-grants-2014_01 |