HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475822Generated: October 30, 2026
Ammonium Hydroxide → 8-(3,5-difluorophenyl)-7,8-dihydro-1H-pyrano[4,3-d]pyrimidine-2,4(3H,5H)-dione
https://huagongshe.com/reaction/475822
Participants
| Role | Name | HCID | Charge |
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| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 8-(3,5-difluorophenyl)-7,8-dihydropyrano[3,4-e][1,3]oxazine-2,4(3H,5H)-dione | HCID 58075376 | — |
| Product | Nitrogen | HCID 947 | — |
| Product | 8-(3,5-difluorophenyl)-7,8-dihydro-1H-pyrano[4,3-d]pyrimidine-2,4(3H,5H)-dione | HCID 58075474 | 166.7% |
Reaction Steps
The mixture of 8-(3,5-difluorophenyl)-7,8-dihydropyrano[3,4-e][1,3]oxazine-2,4(3H,5H)-dione (Preparation X3) (230 mg, 0.818 mmol) and ammonium hydroxide (2229 μL, 57.3 mmol) in a sealed bottle was heated at 80° C. for 4 h. Blowed by N2 overnight to get 8-(3,5-difluorophenyl)-7,8-dihydro-1H-pyrano[4,3-d]pyrimidine-2,4(3H,5H)-dione (191 mg, 0.682 mmol, 83% yield) which was used as is. LC-MS (M+H)+=281.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08637525B2 |
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| Source dataset | uspto-grants-2014_01 |
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| ORD ID | ord-936342f26c034fe48c9ba5e666122473 |
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| Source note | uspto-grants-2014_01 |
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