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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 475830Generated: October 29, 2026

Isocyanatocarbonyl chloride → 8-(4-(trifluoromethyl)phenyl)-7,8-dihydropyrano[3,4-e][1,3]oxazine-2,4(3H,5H)-dione

https://huagongshe.com/reaction/475830

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIsocyanatocarbonyl chlorideHCID 119708—
Reactant3-(4-(trifluoromethyl)phenyl)dihydro-2H-pyran-4(3H)-oneHCID 58075307—
Product8-(4-(trifluoromethyl)phenyl)-7,8-dihydropyrano[3,4-e][1,3]oxazine-2,4(3H,5H)-dioneHCID 58075839—

Reaction Steps

3-(4-(trifluoromethyl)phenyl)dihydro-2H-pyran-4(3H)-one (Intermediate Z(2)) was reacted as described in Intermediate X(3) with carbonisocyanatidic chloride to give 8-(4-(trifluoromethyl)phenyl)-7,8-dihydropyrano[3,4-e][1,3]oxazine-2,4(3H,5H)-dione (Intermediate Z(3)).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08637525B2
Source datasetuspto-grants-2014_01
ORD IDord-bb2d27acbdb74649892da9a8dc324236
Source noteuspto-grants-2014_01