反应详情

温度

0 °C

Amlodipine free base (4.09 g) was added to 40 mL of ethanol. The mixture was heated at reflux and stirred until the solid was completely dissolved. Nicotinic acid (1.23 g) was added to the amlodipine solution and then the mixture was slowly cooled down to 0° C. within one hour. The solids formed were isolated by filtration, washed with ethyl acetate and dried under reduced pressure to yield 4.51 g of amlodipine nicotinate.

1. temperatureThe mixture was heated
2. temperatureat reflux
3. dissolutionwas completely dissolved
4. customThe solids formed
5. customwere isolated by filtration
6. washwashed with ethyl acetate
7. customdried under reduced pressure