反应详情

A solution of 100 mg of [5-(3,5-dichlorophenylthio)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-phenyl-methanone and 23 mg of sodium borohydride in 5 ml of methanol was stirred at rt for 17 h. The mixture was diluted with 4 ml of water and extracted four times with diethyl ether. Combined extracts were dried over magnesium sulphate, filtered and evaporated. The residue was purified by flash chromatography on silica gel using ethyl acetate/petroleum spirit 40°-60° C. for the elution to give 84 mg of [5-(3,5-dichlorophenylthio)-3-methyl-1-phenyl-1H-pyrazol-4-yl]-phenyl-methanol as a colourless gum. Mass spectrum (EI) m/z 440 [M]+.

1. extractionextracted four times with diethyl ether
2. dry with materialCombined extracts were dried over magnesium sulphate
3. filtrationfiltered
4. customevaporated
5. customThe residue was purified by flash chromatography on silica gel
6. customethyl acetate/petroleum spirit 40°-60° C.
7. washfor the elution