1,2-Dichloroethane → HCID 68078594, compound

Participants

Reaction Steps

The title compound was prepared in the same manner as described in example 109 using 1-(1-methylethyl)-6-(4-pyridinyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (60 mg, 0.213 mmol), DMSO (2 mL), 3-(aminomethyl)-4,6-dimethyl-2(1H)-pyridinone (60.1 mg, 0.319 mmol) HCl salt, N-methylmorpholine (0.093 mL, 0.850 mmol), 1-hydroxy-7-azabenzotriazole (57.9 mg, 0.425 mmol), and EDC (81 mg, 0.425 mmol). The final product was collected as 66 mg (74%). LCMS E-S (M+H)=446.5. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.56 (d, J=6.0 Hz, 6H), 2.13 (br. s., 3H), 2.23 (br. s., 3H), 4.43 (m, 2H), 5.37 (m, 1H), 5.91 (br. s., 1H), 8.15-8.34 (m, 3H), 8.44 (s, 1H), 8.78 (br. s., 2H), 9.00 (br. s., 1H), 11.58 (br. s., 1H).

Provenance & Evidence