Diethyl Oxalate → Ethyl 4-[4-(methylthio)phenyl]-2,4-dioxobutanoate

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The title compound was prepared in the same manner as for intermediate 66 using sodium metal (0.160 g, 6.95 mmol), 1-[4-(methylthio)phenyl]ethanone (1.05 g, 6.32 mmol) and diethyl ethanedioate (0.856 mL, 6.32 mmol). The product was collected as 1.58 g (59%). LCMS E-S (M+H)=266.9. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.29-1.50 (m, 3H), 2.41-2.62 (m, 3H), 4.23-4.49 (m, 2H), 7.15-7.38 (m, 2H), 7.89 (dd, J=8.72, 2.15 Hz, 2H).

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