2,3-Dihydro-1-benzofuran-4-amine → 17-[2-Ethoxy-8,9-dihydrofuro[2,3-h]quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid

HRID 476139Notes

Reaction equation

HRID 476139 reaction equation
NC1C2CCOC=2C=CC=1.[CH2:11]([O:13][C:14]1[CH:23]=[C:22]([O:24][CH:25]2[CH2:42][CH:41]3[CH:27]([C:28](=[O:48])[N:29]([CH3:47])[CH2:30][CH2:31][CH2:32][CH2:33][CH:34]=[CH:35][CH:36]4[C:38]([C:44]([OH:46])=[O:45])([NH:39][C:40]3=[O:43])[CH2:37]4)[CH2:26]2)[C:21]2[C:16](=[C:17]([CH3:51])[C:18]([O:49][CH3:50])=[CH:19][CH:20]=2)[N:15]=1)[CH3:12]>>[CH2:11]([O:13][C:14]1[CH:23]=[C:22]([O:24][CH:25]2[CH2:42][CH:41]3[CH:27]([C:28](=[O:48])[N:29]([CH3:47])[CH2:30][CH2:31][CH2:32][CH2:33][CH:34]=[CH:35][CH:36]4[C:38]([C:44]([OH:46])=[O:45])([NH:39][C:40]3=[O:43])[CH2:37]4)[CH2:26]2)[C:21]2[C:16](=[C:17]3[CH2:51][CH2:50][O:49][C:18]3=[CH:19][CH:20]=2)[N:15]=1)[CH3:12]

Participants

3

Reactant 2

HCID 117010432,3-Dihydro-1-benzofuran-4-amineHCID 6869453817-[2-Ethoxy-7-methoxy-8-methylquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid

Product 1

HCID 6868992117-[2-Ethoxy-8,9-dihydrofuro[2,3-h]quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid

Procedure

The title compound (8) was prepared from 4-amino-2,3-dihydrobenzofurane following the procedure (Steps A-J) reported for synthesis of 17-[2-ethoxy-7-methoxy-8-methylquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.046]-octadec-7-ene-4-carboxylic acid (2): m/z=564 (M+H)+.

Sources & evidence

ORD record
ord-5a41f59bf9044ea292e8176850d175f0
Source dataset
uspto-grants-2014_01
Patent number
US08637663B2

Reaction notes

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