17-[2-Ethoxy-8,9-dihydrofuro[2,3-h]quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid → N-[17-[2-ethoxy-8,9-dihydrofuro[2,3-h]quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclo-propyl)sulfonamide

HRID 476140Notes

Reaction equation

HRID 476140 reaction equation
C(OC1C=C(OC2CC3C(C(=O)N(C)CCCCC=CC4C(C(O)=O)(NC3=O)C4)C2)C2C(=C3CCOC3=CC=2)N=1)C.[CH2:42]([O:44][C:45]1[CH:54]=[C:53]([O:55][CH:56]2[CH2:73][CH:72]3[CH:58]([C:59](=[O:85])[N:60]([CH3:84])[CH2:61][CH2:62][CH2:63][CH2:64][CH:65]=[CH:66][CH:67]4[C:69]([C:75]([NH:77][S:78]([CH:81]5[CH2:83][CH2:82]5)(=[O:80])=[O:79])=[O:76])([NH:70][C:71]3=[O:74])[CH2:68]4)[CH2:57]2)[C:52]2[C:47](=[C:48]([CH3:88])[C:49]([O:86][CH3:87])=[CH:50][CH:51]=2)[N:46]=1)[CH3:43]>>[CH2:42]([O:44][C:45]1[CH:54]=[C:53]([O:55][CH:56]2[CH2:73][CH:72]3[CH:58]([C:59](=[O:85])[N:60]([CH3:84])[CH2:61][CH2:62][CH2:63][CH2:64][CH:65]=[CH:66][CH:67]4[C:69]([C:75]([NH:77][S:78]([CH:81]5[CH2:83][CH2:82]5)(=[O:79])=[O:80])=[O:76])([NH:70][C:71]3=[O:74])[CH2:68]4)[CH2:57]2)[C:52]2[C:47](=[C:48]3[CH2:88][CH2:87][O:86][C:49]3=[CH:50][CH:51]=2)[N:46]=1)[CH3:43]

Participants

3

Reactant 2

HCID 6868992117-[2-Ethoxy-8,9-dihydrofuro[2,3-h]quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acidHCID 68696188N-[17-[2-ethoxy-7-methoxy-8-methylquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl] (cyclo-propyl)sulfonamide

Product 1

HCID 74348516N-[17-[2-ethoxy-8,9-dihydrofuro[2,3-h]quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclo-propyl)sulfonamide

Procedure

The title compound (9) was prepared from 17-[2-ethoxy-8,9-dihydrofuro[2,3-h]-quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid (8) following the procedure reported for synthesis of N-[17-[2-ethoxy-7-methoxy-8-methylquinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamide (3): m/z=667 (M+H)+.

Sources & evidence

ORD record
ord-9eadfadcaea9460dbd80e9c9685eec36
Source dataset
uspto-grants-2014_01
Patent number
US08637663B2

Reaction notes

Loading…